Antithyroid effects of lithium

Toxic Effects of Antithyroid Drugs *

The first studies on thiourea in this department were undertaken for reasons quite apart from the purposes for which it is now used. It had been reported that this compound distributed itself uniformly throughout the fluids of the body, that it was excreted like urea and could be recovered in the urine, completely, unchanged.31 These characteristics, if they could be verified, would make thiour...

Antithyroid Drugs

The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), andpropylthiouracil (PTU) have extensively been used in the management of various forms ofhyperthyroidism over the past eight decades. This review aims to summarize different aspectsof these outstanding medications. Thionamides have shown their own acceptable efficacy andeven safety profiles in ...

Antithyroid Drugs

The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), andpropylthiouracil (PTU) have extensively been used in the management of various forms ofhyperthyroidism over the past eight decades. This review aims to summarize different aspectsof these outstanding medications. Thionamides have shown their own acceptable efficacy andeven safety profiles in ...

TERATOGENIC EFFECTS OF LITHIUM CARBONATE ON DEVELOPMENT OF MOUSE EMBRYOS

Effects of lithium ions

In spite of the abundant literature, questions on the biological action of Li' are far from being answered. In the present paper we demonstrate that modification of the salt composition of the medium for actin polymerization, by gradually replacing K+ with Li', leads to a dose-related change in the time course of actin assembly. The presence of Li' influences actin polymerization in vitro by en...